Ultra Liver is a dietary supplement by UpWellness, LLC, formulated by naturopathic physician Dr. Joshua Levitt, ND, with 10 active ingredients targeting liver function, bile support, and detoxification in adults. Each bottle delivers a 30-day supply at the recommended two capsules daily dose.
The formula combines milk thistle, TMG, NAC, taurine, berberine, glutathione, artichoke leaf, dandelion root, reishi mushroom, and schisandra berry. Customer reviews on Amazon average 4.3 out of 5 stars from over 1,167 verified buyers. The product sells for $49.99 per bottle (USD), with a Subscribe & Save option reducing the cost to $39.99 monthly.
This review covers the full ingredient science, documented side effect risks, real customer feedback from over 1,167 Amazon reviewers, and whether Ultra Liver delivers enough evidence-backed value to justify its premium price for general liver nutritional support in healthy adults.
What Is Ultra Liver?
Ultra Liver is a liver health supplement produced by UpWellness, LLC, formulated with 10 active ingredients to support liver function, detoxification, and gallbladder health. It comes in capsule form and targets adults looking to maintain liver enzyme levels and bile quality.
Here’s the thing: each bottle contains 60 capsules. Each bottle delivers a 30-day supply at two capsules daily. The formula combines botanical extracts, amino acid derivatives, and antioxidants in one product.
UpWellness positions Ultra Liver as a broad-spectrum liver support formula rather than a single-ingredient supplement. The product has accumulated over 1,167 customer reviews on Amazon with a 4.3 out of 5 rating.
Who Makes Ultra Liver?
Ultra Liver is produced by UpWellness, LLC, a naturopathic supplement company co-founded by Dr. Joshua Levitt, ND, his wife Dr. Amanda Levitt, ND, and Jake Carney. Dr. Joshua Levitt holds over 20 years of clinical experience in naturopathic medicine, according to the brand’s official product page.
The formula is physician-developed and manufactured in the USA. UpWellness states the product is designed to complement a health-conscious lifestyle, not replace medical care.
What Form Does Ultra Liver Come In?
Ultra Liver comes in capsule form with 60 capsules per bottle. Each bottle provides a 30-day supply at the brand’s recommended dose of two capsules daily. Each serving is best taken one to two hours after a meal. The capsules can be split between morning and evening.
Multiple pack sizes are available, including single bottles, packs of three, and packs of five. UpWellness also offers a subscription option with a 15% discount on recurring orders, with delivery intervals ranging from two weeks to six months.
What Ingredients Are in Ultra Liver?
Ultra Liver contains 10 active ingredients: TMG (Trimethylglycine), NAC (N-Acetylcysteine), Taurine, Milk Thistle, Artichoke Leaf, Reishi Mushroom, Schisandra Berry, Berberine, Glutathione, and Dandelion Root. Each ingredient targets a specific aspect of liver or gallbladder health.
In fact, this combination covers bile production, liver enzyme balance, antioxidant defense, and immune function simultaneously. UpWellness markets the blend as synergistic. The ingredients are designed to amplify each other’s effects.
Key Ingredients:
- TMG (Trimethylglycine) – bile and liver defense support
- NAC (N-Acetylcysteine) – precursor to glutathione, antioxidant support
- Milk Thistle (silymarin) – most studied liver-support botanical
- Artichoke Leaf – bile flow and liver enzyme support
- Dandelion Root – bile production and detox support
- Berberine – liver enzyme and lipid metabolism support
- Reishi Mushroom – immune modulation
- Schisandra Berry – hepatoprotective adaptogen
- Taurine – bile salt synthesis support
- Glutathione – master antioxidant for liver cell protection
Does Ultra Liver Contain Milk Thistle?
Yes. Ultra Liver contains milk thistle (silymarin) as one of its 10 active ingredients, consistent with the most commonly used botanical in liver supplements on the market. A University of New Mexico study found milk thistle was present in 19 out of 20 top-selling liver supplements on Amazon.
Does milk thistle actually work? A 2017 PubMed analysis found silymarin slightly reduced certain liver enzymes in people with liver disease. That said, a Cochrane Review of 18 milk thistle studies noted limited effects on liver disease complications versus placebo, with many studies of poor quality.
The specific silymarin dose in Ultra Liver’s formula is not publicly disclosed. This limits independent assessment of whether the amount aligns with doses used in clinical research.
What Does TMG Do in Ultra Liver?
TMG (Trimethylglycine) serves as the primary hepatoprotective compound in Ultra Liver. It fortifies liver cell defenses against damage and optimizes the liver’s natural repair process. Dr. Joshua Levitt describes TMG as ‘the liver’s coat of armor.’
Here’s why that matters: TMG donates methyl groups to support methylation, a biochemical process essential for liver detoxification and the synthesis of key compounds like SAMe. This mechanism is biologically plausible, but no finished-product research on Ultra Liver’s specific formula has verified it independently.
How Does Ultra Liver Work?
Ultra Liver works by combining ingredients that target multiple liver functions simultaneously: bile production, enzyme regulation, antioxidant defense, and toxin processing. The formula supports the liver’s existing filtration systems rather than replacing them.
Think of it this way: the liver filters approximately 1.5 liters (about 50 oz) of blood per minute. The organ breaks down medications, alcohol, and dietary toxins. Ultra Liver’s ingredients are intended to supply the nutrients these enzyme systems require to function at capacity.
Bottom line: no independent clinical study on the complete Ultra Liver formula exists in peer-reviewed literature. Individual ingredient research is available, but its translation to the finished product remains independently unverified.
How Ultra Liver Targets the Liver:
- Supplies methyl donors (TMG) to support liver methylation and SAMe synthesis.
- Provides antioxidants (NAC, glutathione) to reduce oxidative stress on liver cells.
- Delivers choleretics (artichoke leaf, dandelion root) to stimulate bile production.
- Includes hepatoprotective botanicals (milk thistle, schisandra berry) to protect liver tissue.
Does Ultra Liver Support Bile Flow?
Yes. Ultra Liver contains multiple ingredients with documented mechanisms related to bile production and bile salt synthesis. These include taurine, artichoke leaf, dandelion root, and TMG. The brand claims the formula is uniquely designed to ‘thin bile’ and support gallbladder health.
Here’s what the science shows: taurine plays a role in conjugating bile acids into bile salts, which are essential for fat digestion. Artichoke leaf has been studied for increasing bile production. Dandelion root has traditionally functioned as a choleretic. It stimulates bile secretion from the gallbladder.
The claim that Ultra Liver is ‘the only formula designed to thin bile’ is brand positioning language, not a verified clinical finding. Whether the specific doses achieve measurable bile-related effects is not independently verifiable from published research.
What Are the Benefits of Ultra Liver?
Ultra Liver is marketed to deliver liver detox support, improved bile quality, enhanced energy levels, immunity support, and overall wellness through its 10-ingredient formula. UpWellness attributes these benefits to the synergistic action of the botanical and nutritional compounds in each capsule.
To be clear: the liver regulates blood sugar, filters toxins, metabolizes fat, and produces bile. Supplementing nutrients involved in these processes may support liver efficiency in individuals with nutritional deficiencies or high toxic load.
All health claims on the Ultra Liver product label are brand claims. The FDA has not evaluated them. No peer-reviewed clinical trial on the finished Ultra Liver formula has been published as of 2025.
Does Ultra Liver Boost Energy?
Yes. Ultra Liver claims to support energy levels through NAC, berberine, and TMG, which are involved in cellular energy metabolism and mitochondrial support. Several verified customer reviews report noticeable energy improvements within two to four weeks of consistent use.
In fact, one verified Amazon reviewer noted feeling ‘more energetic and an overall feeling better’ after 25 days of taking Ultra Liver. This matches the product’s marketing claims but reflects individual user experience, not clinical outcome data.
So what does that mean for you? Berberine activates AMPK, an enzyme that regulates cellular energy use. NAC supports glutathione synthesis. This process reduces oxidative stress that can impair mitochondrial function. These mechanisms are plausible, but not proven at Ultra Liver’s specific dosage levels.
Does Ultra Liver Support Detoxification?
Yes. Ultra Liver contains NAC, glutathione, and milk thistle, which are among the most studied compounds for supporting the liver’s Phase I and Phase II detoxification enzyme systems. These pathways break down and excrete drugs, alcohol, and environmental toxins from the bloodstream.
NAC is a direct precursor to glutathione, the liver’s primary antioxidant and detox compound. Glutathione is also included directly in the formula, though oral bioavailability of supplemental glutathione remains debated in research literature.
Here’s the part most people miss: GoodRx Health, reviewed by Sophie Vergnaud, MD, notes that ‘liver detox’ as a supplement concept is largely false advertising. Supporting liver nutrition differs from actively detoxifying the organ, which the liver performs continuously and autonomously.
What Do Ultra Liver Reviews Say?
Ultra Liver holds a 4.3 out of 5 star average from 1,167 verified customer reviews on Amazon, with over 2,000 units purchased in the past month as of mid-2025. That’s strong commercial traction for a premium-priced liver supplement.
Worth knowing: a University of New Mexico study in the American Journal of Gastroenterology analyzed the top 20 liver supplements on Amazon and found average product ratings of 4.4 out of 5 stars, with review reliability averaging 73% plus or minus 20%. Ultra Liver’s review pool falls within that context.
What Are the Positive Ultra Liver Reviews?
Positive Ultra Liver reviewers most frequently report improved energy levels, a general sense of feeling better, and appreciation for the 10-ingredient formula’s comprehensive approach to liver support. Multiple reviewers note noticeable changes within two to four weeks of daily use.
Amazon reviewers describe the product with phrases like ‘great product for liver health,’ ‘fabulous product,’ and ‘best liver bile health.’ Many users include Ultra Liver as part of a broader detox or wellness program rather than a standalone solution.
Dr. Joshua Levitt, the formula’s developer, states Ultra Liver ‘delivers meaningful improvements in liver function and enzyme levels in people who need liver support.’ The good news? This is a direct physician endorsement of the formula. The honest read: it’s a brand claim from the product’s own developer, not an independent clinical finding.
What Are the Common Ultra Liver Complaints?
The most notable concern in Ultra Liver reviews comes from users who reported no perceivable effect after a full course, and from a reviewer who flagged that reishi mushroom can boost the immune system, which may worsen autoimmune conditions. These are real limitations buyers should factor in.
The $49.99 (USD) per bottle price for a 30-day supply is also cited as a concern relative to unverified efficacy claims. Individual ingredient doses are not fully disclosed on the label, which limits the ability to assess clinical alignment.
Common Complaints:
- No noticeable effect for some users after a full course
- Reishi mushroom may worsen autoimmune conditions
- Price of $49.99 per month with no independent clinical backing
- Individual ingredient doses not fully disclosed on the label
What Are the Side Effects of Ultra Liver?
Ultra Liver contains reishi mushroom, which has documented immune-stimulating properties that may worsen autoimmune conditions such as rheumatoid arthritis, lupus, or multiple sclerosis in susceptible individuals. This risk is flagged directly by Amazon reviewers.
Berberine, another active ingredient, interacts with certain medications including blood thinners, diabetes drugs, and antibiotics. Individuals on prescription medication should consult a physician before starting Ultra Liver.
And here’s what’s important: NAC at high doses may cause nausea, vomiting, or headache in some users. Dr. Pratima Dibba, a board-certified gastroenterologist with Medical Offices of Manhattan, warns that some liver supplements can cause drug-induced liver injury in vulnerable individuals.
Who Should Avoid Ultra Liver?
Ultra Liver should be avoided by individuals with autoimmune diseases. Pregnant women, nursing mothers, and people taking prescription medications should also consult a physician before use. per UpWellness’s own advisory on the product page. These restrictions are not unique to Ultra Liver but apply broadly to supplement use.
Pieter Cohen, MD, an associate professor at Harvard Medical School, warns that liver supplements ‘may have compounds that may irritate the liver and do more damage’ in vulnerable individuals. Children, adolescents, and anyone with a pre-existing liver condition should not use this product without medical guidance.
Is Ultra Liver FDA Approved?
No. Ultra Liver is not FDA approved, as it is classified as a dietary supplement, a category that does not require FDA review before entering the US market. The FDA does not evaluate dietary supplements for safety or efficacy prior to sale.
The FDA’s own guidance states: ‘If a supplement promises a cure or quick fix for a health problem, it is probably too good to be true.’ The Ultra Liver label carries the standard disclaimer that claims haven’t been evaluated by the FDA.
To put it simply: dietary supplement classification means the brand is responsible for ensuring safety, not the FDA. UpWellness does not prominently disclose third-party testing certifications in competitor review summaries, unlike some competing formulas that market GMP-certified and third-party-tested manufacturing.
How Much Does Ultra Liver Cost?
Ultra Liver is priced at $49.99 per bottle on Amazon. The per-capsule cost is $0.83, or approximately $1.67 per day at the recommended two-capsule serving. A 20% Subscribe & Save discount brings the monthly cost down to approximately $39.99 (USD).
Ultra Liver Pricing:
| Option | Price (USD) | Per Day |
| Single bottle (60 capsules) | $49.99 | $1.67 |
| Subscribe & Save (20% off) | $39.99 | $1.33 |
| 3-pack option | Lower per unit | Lower per day |
Subscription delivery intervals range from two weeks to six months, and UpWellness states subscriptions can be skipped or cancelled at any time, with no lock-in commitment disclosed.
Is Ultra Liver Worth the Price?
Yes and no. Ultra Liver’s price sits above average for the liver supplement category, which a University of New Mexico study found generates over $38 million in annual sales from just the top 20 Amazon products alone. The $49.99 price point reflects the 10-ingredient formula and physician-formulated branding.
Comparable competing formulas include LivUltra by Natures Zest (23 ingredients, 180 capsules, two-month supply) and LifeSource Vitamins Ultra Liver Complex (32 ingredients, 90 tablets). These alternatives offer higher ingredient counts at varying price tiers for buyers comparing options.
Short answer: without independent clinical evidence on the specific formula, the value proposition rests on ingredient quality and brand credibility. For users who prioritize physician-developed branding and a 10-ingredient synergistic blend, the premium may be justified. For buyers requiring clinical proof, the evidence base is limited.
Ultra Liver vs Competitors:
| Product | Ingredients | Price (USD) | Supply |
| Ultra Liver (UpWellness) | 10 active | $49.99 | 30 days |
| LivUltra (Natures Zest) | 23 active | Lower tier | 60 days |
| Ultra Liver Complex (LifeSource) | 32 synergistic | Varies | 90 tablets |
Where Can You Buy Ultra Liver?
Ultra Liver is available on Amazon with Prime eligibility for US domestic shipping within two to three business days, and directly through the UpWellness official website. Amazon offers multiple pack sizes including single bottles, three-packs, and five-packs.
The Subscribe & Save program on Amazon delivers the lowest per-unit cost. Over 2,000 units were purchased through Amazon in the month preceding mid-2025. This signals consistent consumer demand for the product.
Is Ultra Liver Worth It?
It depends. Ultra Liver delivers a credible 10-ingredient formula targeting liver health, gallbladder support, and detoxification, but lacks independent clinical evidence needed to verify its specific efficacy claims. The product is best understood as nutritional support, not a medically proven liver treatment.
The ingredients are individually plausible for liver support. The positive review volume on Amazon suggests many users experience benefits. The reishi mushroom caution for autoimmune conditions and the absence of disclosed ingredient doses are limitations buyers should weigh before purchasing.
The good news? Physicians including Dr. Pratima Dibba (Medical Offices of Manhattan) and Dr. Pieter Cohen (Harvard Medical School) recommend caution with liver supplements as a category, which means doing due diligence on the formula is the right call. For individuals in good health seeking general liver nutritional support, Ultra Liver is a well-formulated option at a premium price. Anyone with liver disease or active medical conditions should consult a physician before use.